Influenza virus replication, efficacy against

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Removal of the C-8 and C-9 hydroxy groups in order to produce a hydro-phobic side-chain, gave such derivatives as 67, which were evaluated against influenza A and B virus sialidases and used in a viral-replication assay.82 While these molecules displayed similar efficacy to the parent triol against influenza A virus sialidase, they were relatively ineffective against influenza B virus. 

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