Inflammatory response, Wolbachia

Brattig, N.W., Rathjens, U., Ernst, M., Geisinger, F., Tischendorf, F.W. and Renz, A. (2000) Lipopolysaccharide-like molecules from Wolbachia endobacteria of the filaria Onchocerca volvulus are candidate mediators in the sequence of inflammatory and anti-inflammatory responses of human monocytes. Microbes and Infection2, 1—11. 

Ford, L., Prasad, G.B.K.S., Wu, Y., Cross, H. and Taylor, M.J. (2000) Filarial Wolbachia HSP60 and LPS share common pathways in the activation of inflammatory responses. In First International Wolbachia Conference (Kolymbari, Crete, Greece, 7-12 June 2000), abstract book, pp. 125-126. 

Taylor, M.J., Cross, H.F. and Bilo, K. (2000) Inflammatory responses induced by the filarial nematode Brugia malayi are mediated by lipopolysaccharide-like activity from endosymbiotic Wolbachia bacteria. Journal of Experimental Medicine 191, 1429-1436. 

A role for the release of Wolbachia bacterial endosym-bionts has been suggested in the pathogenesis of the Mazzotti reaction (SEDA-26, 345). There was a good correlation between Wolbachia DNA, serum TNF-alfa, and the antibacterial peptides calprotectin and calgranu-lin after treatment with ivermectin or diethylcarbamazine, supporting a role for Wolbachia products in mediating these inflammatory responses (27). 

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