Induction in Other Organs and Tissues

In contrast to liver, Octl was not induced by PCN in the kidney of rats, whereas Oct2 (Slc22a2) was induced [130], 

2 Blood-Brain Barrier. PXR has been shown to be expressed in rat brain capillaries and treatment of isolated capillaries with PCN and dexamethasone in 

In breast cancer cells ZR-75-1 and T-47D, which also express only low levels of endogenous PXR, treatment with rifampin transiently induces the expression of SLCO1A2 mRNA in a dose- and time-dependent manner [114], Induction by rifampin was shown to be independent of de novo protein biosynthesis. In contrast to SLC01A2, MDR1 was not induced [114], The physiological relevance of these findings has to await further clarification. 

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