Induced-fit principle

Fig. 4.12. Illustration of the induced fit principle in the case of a cyclen derivative, DOTA (top), of podands (middle) and of self-assembly processes (bottom).

Fig. 2. Principle mechanisms of formation of a receptor—substrate complex (a) Fischer s rigid "lock-and-key" model (b) "induced fit" model showing...

According to current understanding, binding by an induced-fit mechanism seems to be a unique property of small-molecule-binding RNA aptamers. This property of aptamers might have inspired the idea of fusing aptamer sequences with known catalytic RNAs to introduce the principle of allosteric regulation into ribozyme catalysis. None of the ribo-zymes described so far was known to operate as allosteric enzymes in vitro or in vivo. 

General Principles The Induced Fit Model (Figure 11.7, Figure 11.8, Reaction)... 

Approaches for fully flexible docking either follow a conformational selection or an induced fit concept (Figure 8.3). Ensemble docking implements the principle of conformational selection and relies on the protein structural change occurring before the ligand binds to the protein. The ensemble of input protein conformations... 

Cryptands, p. 334 Hydrogen Bonding, p. 658 Induced Fit, p. 717 The Lock and Key Principle, p. 809 Selectivity Thermodynamic and Kinetic, p. 1225 Self-Assembly Definition and Kinetic and Thermodynamic Considerations, p. 1248... 

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