Indoprofene

An isoindol1 none moiety forms part of the aromatic moiety of yet another antiinflammatory propionic acid derivative. Carboxylation of the anion from -nitro-ethylbenzene (45) leads directly to the propionic acid (46). Reduction of the nitro group followed by condensation of the resulting aniline (47) with phthalic anhydride affords the corresponding phthalimide (48). Treatment of that intermediate with zinc in acetic acid interestingly results in reduction of only one of the carbonyl groups to afford the isoindolone. There is thus obtained indoprofen (49). ... 

Cj H403 85-44-9) sec Anisindione Chlortalidone Cilazapril Deptropine Fluorescein Hydralazine Indobufen Indoprofen Melphalan Phenolphthalein Phthalylsulfathiazole Pizotifen Pramipexole hydrochloride Saquinavir Sulfaloxic acid Thalidomide Tilisolol hydrochloride phthalide... 

The analgesic and anti-inflammatory Indoprofene (42) can be made by several routes, two of which involve cyclisations. Treatment of phthalic anhydride with amino acid (43) gives imide (45) in one step - the cyclisatlon of (44) must be faster than the inter-molecular reaction by which it is formed. Reduction of (45) give.s Indoprofene as the reactive imide is easily reduced as far as the unreactive amide. 

Major drugs withdrawn between 1971 and 1982 for safety reasons included polidexide (introduced 1974 and withdrawn 1975), oral formulation of practolol (1970 and 1976), alclofenac (1972 and 1979), tienilic acid (1979 and 1980), clomacron (1977 and 1982) and indoprofen (1982 and 1982). 

Carprofen, flurbiprofen, keto-profen, naproxen, suprofen, pranoprofen, indoprofen 8, HP-/8, HP-y, DM-/8, TM-/8... 

Lelievre and Gareil (31) studied chiral separations of nonsteroidal anti-inflammatory drugs (carprofen, flurbiprofen, indoprofen, ketoprofen, naproxen, propafenone, and suprofen) and determined the acidity and inclusion complex formation constants of these chiral compounds with different neutral CDs (/3-CD, HP-/3-CD, DM-/3-CD, TM-/3-CD, and HP-y-CD). In... 

Tg values of dextran-rich phase when compared neat dextran (inset). The solid solubility of trehalose was determined to be at 12% w/w sftCS/05% RH conditions. In another study, changes in thfFg of griseofulvin-PVP and indoprofen-PVP solid dispersions were measured for up to 3 months by storing them at 40/70% RH conditions (Figure 18.13). While griseofulvin-PVP... 

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