Indomethacin-loaded polymer

Figure 6. Positive ion SSIMS spectrum of 10% wt/wt indomethacin loaded polymer beads.

Nanospheres of PLGA were prepared by emulsion-evaporation by employing homogenization and a solvent system consisting of acetone in which both the drug and polymer were dissolved [95], The encapsulation of 5FU in these nanospheres was low compared to the more hydrophobic drug, indomethacin. It was reported that the hydrophilic 5FU leaked to the aqueous phase. PGL nanoparticles were prepared by aldol condensation loading 5FU with an efficiency of 14.32% [50]. 

The mechanism of the drug release appeared to be simple diffusion from an EC matrix tablet and the data could be adequately described by the Higuchi square root of time relationship for water-soluble pseudophedrine hydrochloride at 12.5-25 % drug loading [309]. Release of the slightly soluble theophylline or the practically insoluble indomethacin from such tablets at 50 % or 25 % drug loading, respectively, was described by diffusion with polymer relaxation and erosion contributions to the release mechanism [313]. 

M. Timko et ah. Magnetite polymer nanospheres loaded by Indomethacin for anti-inflammatory therapy. Journal of Magnetism and Magnetic Materials, 300(1), 191-194 (2006). 

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