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Indomethacin in rheumatoid arthritis

Two pyrrole derivatives bearing a significant structural resemblence to indomethacin are tolmetin (10) and chlopirac (11) (78MI30600, 76MI30600). Tolmetin has received clinical comparison with aspirin and with indomethacin in rheumatoid arthritis and generally was found to have comparable effectiveness, but a somewhat diminished tendency to cause lesions in the digestive tract. Like indomethacin, it seems to function as a prostaglandin synthetase inhibitor. [Pg.371]

Rudge SR, Lloyd-Jones JK, Hind ID. Interaction between flurbiprofen and indomethacin in rheumatoid arthritis. BrJ Clin Pharmacol Q.9S2) 13, 448-51. [Pg.152]


See other pages where Indomethacin in rheumatoid arthritis is mentioned: [Pg.98]   
See also in sourсe #XX -- [ Pg.37 ]

See also in sourсe #XX -- [ Pg.37 ]

See also in sourсe #XX -- [ Pg.1678 ]




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Arthritis, rheumatoid

In rheumatoid arthritis

Indomethacine

Rheumatoid

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