Indolo 7,6-g indole

Other indoles that have been prepared using the Sonogashira coupling and cyclization sequence include 5,7-difluoroindole and 5,6,7-trifluoroindole [219], 4-, 5-, and 7-methoxyindoles and 5-, 6-, and 7-(triisopropylsilyl)oxyindoles [220], the 5,6-dichloroindole SB 242784, a compound in development for the treatment of osteoporosis [221], 5-azaindoles [222], 7-azaindoles [160], 2,2-biindolyls [223,176], 2-octylindole for use in a synthesis of carazostatin [224], chiral indole precursors for syntheses of carbazoquinocins A and D [225], a series of 5,7-disubstituted indoles [226], a pyrrolo[2,3-eJindole [226], an indolo[7,6-g]indole [227], pyrrolo[3,2,l-y]quinolines from 4-arylamino-8-iodoquinolines [228], optically active indol-2-ylarylcarbinols [229], 2-alkynylindoles [176], 7-substituted indoles via the lithiation of the intermediate 2-alkynylaniline derivative [230], and a variety of 2,5,6-trisubstituted indoles [231], This latter study employs tetrabutylammonium fluoride, instead of Cul or alkoxide, to effect the final cyclization of 215 to indoles 216 as summarized here. 

New heterocyclic systems were synthesized - isomeric dipyrrolonaphthalines lH,6H-indolo[7,6-g]indole, 3H,8H-indolo[4,5-... 

In the present work are deseribed synthesis, antimierobial, antituberculous and antifungal activities of some dipyrrolonaphthaline derivatives synthesized earlier by us lH,10H-benzo[e]pyrrolo [3,2-g]indole (I), 3H,8H-indolo[5,4-e]indole(ll), lH,6H-indolo[7,6-g]indole(III) and 3H,8H-indolo[4,5-e]indole (IV) [1-3]. 

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