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Indolizines Mannich reaction

The Mannich reaction, however, is an easily accomplished substitution, occurring in the 1- and 3-positions. The biological activity of numerous Mannich bases of indolizines has been investigated. The 1-substituted indolizines (34) and (35), which have been prepared using a Mannich reaction, may serve as examples (Scheme 6). [Pg.455]

Some indolizine-l-acetic acids (87) have also been prepared137,138 by using the Mannich reaction, and these were found to exhibit analgesic activity. After initial aroylation, reaction with dimethylamine and... [Pg.131]

A new synthesis leading to a previously unknown 8-substituted indolizine involves initially the formation of the dihydropyridopyranyl ether (81) by reaction between a vinyl ether and a Mannich base obtained from 3-hydroxypyridine treatment with dilute hydrochloric acid... [Pg.126]

See other pages where Indolizines Mannich reaction is mentioned: [Pg.700]    [Pg.700]    [Pg.131]    [Pg.131]    [Pg.700]    [Pg.700]    [Pg.962]    [Pg.962]    [Pg.398]    [Pg.962]   
See also in sourсe #XX -- [ Pg.2 ]

See also in sourсe #XX -- [ Pg.962 ]

See also in sourсe #XX -- [ Pg.962 ]

See also in sourсe #XX -- [ Pg.2 ]

See also in sourсe #XX -- [ Pg.962 ]



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