Indolizidine alkaloids from marine sources

Indolizidine and Quinolizidine Alkaloids from Marine Sources... 

INDOLIZIDINE AND QUINOLIZIDINE ALKALOIDS FROM MARINE SOURCES... 

The survey of indolizidine and quinolizidine alkaloids from marine sources in Volume 55 of this series also included alkaloids in which the quinolizidine core was incorporated into more complex macrocychc frameworks. The alkaloids in question included (+)-hahchlorine (2464), an inhibitor of VCAM-1 expression and the saraines, as represented by sar-aine-1 (2465) (Figure 48). Neither now fits the brief of the present review. However, the saraines have been the subject of a very recent review in this series of volumes. 

Indolizidine and quinolizidine alkaloids have been found in different natural sources and have been isolated from amphibians, ants, fungi, marine organisms and plants. Most of them have noxious or toxic properties and... 

Hie first, by Lounastnaa and Hanhinen, updates an area of indole alkaloids which has been neglected in the series for over 30 years, namely, the ajmaline group of alkaloids, where numerous advances in chemistry and biosynthesis have been made recently. The second chapter by Michael reports on the progress made in a vast area of alkaloid chemistry, those alkaloids with either an indolizidine or a quinolizidine nucleus derived from plant, marine animal, and fungal sources. 

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