3- Hydroxymethyl indole

Indole, 3-hydroxymethyl-hydrogenolysis, 4, 273 oxidation, 4, 272 reduetion, 4, 272 stability, 4, 272... 

Indole, 3-hydroxymethyl-2-phenyl-stability, 4, 272 Indole, I-hydroxy-2-phenyl-synthesis, 4, 363 Indole, 2-iodo-synthesis, 4, 216 Indole, 3-iodo-reaetions, 4, 307 synthesis, 4, 216 Indole, 2-iodo-l-methyl-reaetions, 4, 307 Indole, 2-lithio-synthesis, 4, 308 Indole, 3-lithio-synthesis, 4, 308 Indole, 2-mereapto-tautomerism, 4, 38, 199 Indole, 3-mercapto-tautomerism, 4, 38, 199 Indole, 3-methoxy-synthesis, 4, 367 Indole, 5-methoxy-oxidation, 4, 248 Indole, 7-methoxy-2,3-dimethyl-aeetylation, 4, 219 benzoylation, 4, 219 Indole, 5-methoxy-l-methyl-reduetion, 4, 256 Indole, 5-methoxy-l-methyl-3-(2-dimethylaminoethyl)-reaetions... 

The nonaromatic lactones from cis-13, and trcyclohexaneacetic acid14 were important intermediates in the synthesis of indole alkaloids. 

With the use of this methodology, 2,4-dimethylindole, 4-(hydroxymethyl)-2-methylindole, and 4-(methoxymethyl)-2-methylindole are readily obtained, as shown in Eq. 10.63.86 These indoles have been recently isolated from European Basidmycetes.87 Watanabe and coworkers have used a catalytic amount of PdCl2(PPh3)2-SnCl2 under carbon monoxide for reductive iV-heterocyclization of o-nitrostyrenes.88... 

Enamine fragments present in quinolizine systems show their expected behavior as nucleophiles. For example, reaction of the indoloquinolizine derivative 78 with formaldehyde at room temperature afforded the unstable hydroxymethyl derivative 79, while reflux of 78 with formaldehyde under acidic conditions led to indole deprotection and allowed the isolation of the pentacyclic derivative 80 (Scheme 4) <2001TL7237>. 

Carboxy substituted diazepines 226 and 229 react with phenyl isocyanate to afford pyrimido diones 227 and 230, correspondingly (Scheme 48, Section 3.1.1.3 (1993JHC897)). N-Hydroxymethylation on an indole ring annulated to benzaze-pinone, as well as formation of the corresponding carbamate and urea, has been described (2004MI1076). 

Mitomycin Mitomycin is 6-amino-l,la,2,8,8a,8b-hyxahydro-8-hydroxymethyl)-8a-methoxy-5-methylazirino [2, 3 3,4] pyrrolo [l,2-a]indol-4,7-dione carbamate (30.3.6). 

The mechanism of metabolic degradation of indol-3-ylacetic acid (39) is a matter of debate. A possible route demonstrated in vitro includes oxidative decarboxylation to skatolyl hydroperoxide (40), catalyzed by horseradish peroxidase isoenzyme C (HRP-C), followed by rearrangement to 3-(hydroxymethyl)oxindole (41), as shown in equation 12 . 

Pyrazolidine, 1,2-diethyl-3-hydroxymethyl-biological activity, 5, 297 Pyrazolidine, 2-ethoxycarbonyl-1 -phenyl-reactions, 5, 257 Pyrazolidine, 4-hydroxy-synthesis, 5, 155 Pyrazolidine, 1-phenyl-in Fischer indole synthesis, 5, 256 Pyrazolidine, 1 -phenyl-2-(phenylcarbamoyl)-anticonvulsant activity, 5, 297 Pyrazolidine, l-phenyl-2-thiocarbamoyl-synthesis, 5, 257... 

AZIRIN0(2, 3 3.1t)PYRROLO(l,2-a)INDOLE- l,7-DIONE, 6-AMINO-1, la,2,8,8a,8b-HEXAHYDRO-8-(HYDROXYMETHYL)-8a-METHOXY-5-METHYL-,CARBAMATE (ester)... 

The use of dendrimers as soluble supports in combinatorial chemistry was recently introduced by Kim et al. [204] for the synthesis of a 27-member pool library of indoles (three pools by nine individuals). The structure of the dendritic support, which was prepared condensing the commercially available starburst polyamidoamine (PAMAM) dendrimer with the 4-hydroxymethyl benzoic acid (HMB) linker, is given in Figure 7.24. 

I - 3- (1 -metliylctliyl)amino -2-pyridiny 11-4- (5-nitro-111-indol-2-yl)carbonyl)piperazinc (C lH24N,Ov 136817-57-7) see Dclavirdinc incsilatc (l-methylcthyl)carbamic acid 2-(hydroxymethyl)-2-me-thylpcntyl ester... 

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