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Indole Grignard reagents with nitriles

The Fischer indole synthesis has also been employed. The nitrile (XXXVIII) reacts with the Grignard reagent prepared from y-ethoxy-propyl bromide to give an intermediate (XXXIX) which in the presence of acid generates the cyclic ketone XL. The phenylhydrazone of the last can be cyclized to sempervirine (XXXV) (24). [Pg.702]

See other pages where Indole Grignard reagents with nitriles is mentioned: [Pg.73] [Pg.75] [Pg.209] [Pg.210] [Pg.73] [Pg.75] [Pg.41] [Pg.161] [Pg.337] [Pg.17] [Pg.3]

See also in sourсe #XX -- [ Pg.10 , Pg.73 ]

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Grignard reagent nitrile

Grignard reagents with nitriles

Indole Grignard reagents

Nitriles reagents

Reagents indole

With Grignard Reagents