Venlafaxine indinavir

Drugs that may affect venlafaxine include cimetidine, cyproheptadine, and MAOIs. Drugs that may be affected by venlafaxine include clozapine, desipramine, haloperidol, indinavir, St. John s wort, trazodone, sibutramine, sumatriptan, and warfarin. 

Venlafaxine 50 mg 8-hourly reduced the AUC of a single dose of indinavir 800 mg by 28% in nine healthy subjects (39). 

Levin GM, Nelson LA, DeVane CL, Preston SL, Eisele G, Carson SW. A pharmacokinetic drug-drug interaction study of venlafaxine and indinavir. Psychopharmacol Bull 2001 35(2) 62-71. 

In a single-dose study, venlafaxine lowered indinavir levels. 

In a study, 9 healthy subjects were given a single dose of indinavir before and after 10 days of venlafaxine 150 mg daily in divided doses. Indinavir did not affect the pharmacokinetics of venlafaxine, but venlafaxine reduced the AUC and maximum plasma levels of indinavir by 28% and 36%, respectively. This is possibly enough to reduce the efficacy of indinavir. Quite why this happens is not elear. More study is needed to establish the effects of multiple doses. Until more is known it would seem prudent to monitor closely to ensure that the antiviral effects of indinavir are not compromised. 

Jann MW, SpratUn V, Momary K, Zhang H, Turner D, Penzak SR, et al. Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavir. Eur J CHn Pharmacol 2012 68(5) 715-21. 

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