Levodopa Indinavir

Azithromycin, fluoroquinolones, ketoconazole, isoniazid, penicillin, rifampin, and tetracycline ° Didanosine, indinavir, stavudine, and zidovudine ° Aledronate, risedronate, and levodopa... 

An isolated report describes a man taking levodopa who developed severe dyskinesias when given indinavir. 

A 66-year-old man with idiopathic Parkinson s disease and AIDS was free of dyskinesias when taking levodopa with a dopa-decarboxylase inhibitor, although he had unpredictable fluctuations. After 1 month of starting indinavir 2400 mg daily, lamivudine and zidovudine, he developed severe peak-dose dyskinesias, and the on periods lasted all day, with no ftuctu-... 

This appears to be the only report of this possible interaction. Bear in mind the possibility that the levodopa dose may need to be decreased if a protease inhibitor such as indinavir is required. 

---