INDEX valproic acid

Compare the refractive index of the substance to be examined with the refractive index of the reference standard of valproic acid, which has a known refractive index of 1.422-1.425 [10,11],... 

I Advantages. Valproic acid is available in multiple dosage formulations. It has a wide therapeutic index and can be considered a broad-spectrum AED. It also may be useful in other neurologic or psychiatric disorders, including migraine headache and bipolar-affective disorder. 

Colesevelam appears to be less likely to interfere with the absorption of concurrently administered drugs. No significant decreases in absorption were seen when colesevelam was coadministered with either digoxin, lovastatin, warfarin, metoprolol, quinidine, or valproic acid. Because of potential interactions, especially for drugs with a low therapeutic index, the administration of drugs that have not been directly studied in combination with colesevelam should be spaced accordingly, as described above tor cholestryamine and colestipol (7,15). 

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