INDEX unstable units

In this group of reactive and unstable compounds, the common structural feature is an N=N unit double-bonded to a carbon atom. Individually indexed compounds are ... 

The effectiveness of ICRF 159 had led to several other studies. In the People s Republic of China a high therapeutic index has been claimed for bimolane (22, R = H R, = N-methylmorpholine) and this has led to extensive testing in the USA132-1. X-ray diffraction studies of crystals obtained from solutions which initially contained bimolane have demonstrated the formation of ICRF 154 (22, R = Rj = H). Camerman et al.132) have proposed that bimolane is inherently unstable and that the antitumour activity ascribed to it may be attributable to ICRF-154. It is possible that the N-methylmorpholine substituents increase the lipophilicity sufficiently for the basic ICRF-154 unit to be taken up by tumour cells. 

Coacervate drops were quite unstable to pH alterations of the system. The stability of coacervate systems to pH variations was evaluated by measuring the turbidity of systems adjusted to various pH values since turbidity of the mixture serves as an index of the degree of coacervation (17). The coacervate systems formed with gum arabic and protein consisting of 10% kappa-casein and 90% gelatin, at pH 3.8, were most stable at pH 3.8. Some of the coacervates persisted when the pH was varied one pH unit, but were completely dissolved at pH 2.0 and below, and pH 6.0 and above, as shown in Table IV. 

Figure 9. Scattered light intensity / (arbitrary units) as a function of wave vector k and time t for a critical mixture of isobutyric acid and water quenched into the unstable region, k = 47tn/k) sin (6/2), where n is the refractive index, A is the wavelength of the incident beam, and 6 is the scattering angle [122, 5].

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