Incidents exposure, human serum

Measurements of human serum concentrations of endrin following incidents of acute poisoning indicate rapid decline in concentration after exposure (Coble et al. 1967 Rowley et al. 1987). 

Adverse reproductive effects have been observed in animals fed PCB in the diet. Fetal resorptions were common, and dose-related incidences of terata were found in pups and piglets when females were fed Arochlor 1254 at Img/kg/day or more. Long-term low-level maternal exposure of rats before breeding and throughout gestation and lactation caused permanent hearing deficits, decreased serum thyroid hormones, and reproductive effects. PCBs have been observed in human cord blood and in tissues of newborn humans and animals. ... 

In humans, clinical studies of PCB workers reported associations between increased serum levels of liver-related enzymes, lipids, and cholesterol and serum PCBs. Studies of people exposed to PCBs by ingestion of contaminated fish in Triana, Alabama or contaminated rice oil in the Yusho or Yu-Cheng incidents have reported increases in serum levels of some liver enzymes characteristic of microsomal enzyme induction or liver damage, but these effects cannot be attributed solely to PCBs due to the mixed chemical nature of the contaminated fish and heated rice oil exposures. Serum cholesterol, but not triglycerides, was increased in consumers of contaminated fish, whereas increased serum triglycerides, but not cholesterol, were associated with Yusho and Yu-Cheng exposure. 

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