InaD protein

The protein PSD-95 is an example of a PDZ-containing protein (review Craven and Bredt, 1998). PSD-95 is found in postsynaptic cells where, via its PDZ domains, it mediates interactions with intracellular domains of receptors such as the NMDA receptor (see 16.4.2.1). The InaD protein which is composed solely of PDZ domains has an adaptor function in the vision process in Drosophila (see 8.2.5). 

Fig. 8.15 A model of the organization of the InaD signaling complex. InaD is composed of5 PDZ domains (PDZ1-5) which interact specifically with signaling proteins implicated in the vision process in Drosophila. TRP is a K+-channel. PLC is a 6-type phospolipase C, which is the target of rhodopsin-activated Gqa. ePKC is an eye-specific protein kinase C which inactivates the Trp channel by phosphorylation (after Huber, 2001).

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