In toxicology screens

Hopper, D. (1986). Behavioral measures in toxicology screening. In Safety Evaluation of Drugs and Chemicals (Lloyd W., Ed.). Hemisphere Publishing, New York, pp. 305-321. 

It is now 50 years since Russell and Burch, in their classical book on The Principles of Humane Experimental Technique (1), suggested that toxicologists should use small numbers of animals of several inbred strains rather than using outbred stocks in toxicological screening. The aim of this chapter is to explain how... 

Quantification of known analytes in PK and distribution studies makes different demands on the analytical procedure than detection of unknown compounds in biotransformation experiments or identification of unknown and postulated molecules in toxicological screening. For example, requirements for quantitative analysis of fixed analytes with optimum sensitivity and selectivity differ from those for qualitative detection of intact molecular weight or diagnostic MS/MS fragments. Selectivity of sample preparation and applicability of diverse scan modes represent relevant critical issues. The following sections address this context. 

A. Specific levels. Quantitative blood levels are not routinely available and do not help in diagnosis or treatment. Qualitative screening may easily detect phenothiazines in urine or gastric juice, but butyrophenones such as halopeti-dol are usually not included in toxicologic screens (see Table 1-32, p 42). 

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