In situ product removal technique

Recently, an industrial process development for nootkatone production from valencene by microbial transformation (bacteria, fungi) was mentioned [199, 200]. Although no details were given, the author claimed the development of an in situ product-removal technique by which an extremely selective recovery of nootkatone from the reaction mixture and the excess precursor during the proceeding production was achieved and which was said to be essential for an economically viable bioprocess. 

Lye G.J., Woodley J.M., Application of in situ product-removal techniques to biocatalytic processes, Trends Biotechnol. L7, 395-402 (1999)... 

---