Important definitions and descriptions

Please note that in every case, the use must he preceded by observations. 

Generally, the goal of biopharmaceutical studies is to develop a dosage form that will provide consistent bioavailability at a desirable rate. The importance of a consistent bioavailability can be very well appreciated if a drug has a narrow therapeutic range (e.g. dlgoxin) where small variations in blood concentrations may result in toxic or subtherapeutic concentrations. 

Relationship between the administered dose and amount of drug in the body 

Only that fraction of the administered dose which actually reaches the systemic circulation will be available to elicit a pharmacological 

For an intravenous solution, the amount of drug that reaches general circulation is the dose administered. Moreover 

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