Importance and Evolution

MCRs represent a pivotal step in the development of modem chemistry. Unfortunately, many of the aforementioned reactions have only been extensively explored in their racemic version. With all the development that asymmetric catalysis has experienced over the years, new strategies have come to light, which will enable researchers to perform these previously racemic MCRs with stereocontrol. 

The future of this area will most likely rely on the development of techniques that save time, energy, effort, and resources, as well as decrease the amount of waste generated in reactions. The development of the aforementioned computational and analytical techniques will play a vital role in future advances in MCRs. When using these techniques, it 

there are already many examples of MCRs that employ methodologies from green chemistry, such as using reusable catalysts, recyclable solvents, and mechanochem-ical processes. The increase in the use of these techniques and green solvents in MCRs shows that these reactions will evolve along with green chemistry. 

All the reasons mentioned previously make MCRs a valuable and competitive source for synthesizing biologically active products and other compounds with interesting uses in both minor scale and industrial research. 

Bienaym (Eds.) Multicomponent reactions. WUey-VCH Verlag GmbH, Weinheim, Germany, 2005. 

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