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Immunotoxins toxin properties

Figure 21.13 Sulfo-SMCC may be used to activate antibody molecules for coupling to thiolated toxin components. An intact A-B toxin molecule can be modified to contain sulfhydryls by treatment with 2-iminothiolane. Thiolation with this reagent retains the cytotoxic properties of the toxin while generating a sulfhydryl for conjugation. Reaction of the thiolated toxin with the maleimide-activated antibody creates the immunotoxin through thioether bond formation. Figure 21.13 Sulfo-SMCC may be used to activate antibody molecules for coupling to thiolated toxin components. An intact A-B toxin molecule can be modified to contain sulfhydryls by treatment with 2-iminothiolane. Thiolation with this reagent retains the cytotoxic properties of the toxin while generating a sulfhydryl for conjugation. Reaction of the thiolated toxin with the maleimide-activated antibody creates the immunotoxin through thioether bond formation.
ITABLE 13.10. Properties of toxins often used in construction of immunotoxins... [Pg.364]

The potency of an immunotoxin is dependent on the biochemical properties of both the antibody and toxin moieties. Of paramount importance are the characteristics of the target antigen and the antibody affinity for that antigen, rate of internalization into the cell, as well as the efficiency of the intracellular processing and the type of toxin. [Pg.650]

See other pages where Immunotoxins toxin properties is mentioned: [Pg.827]    [Pg.829]    [Pg.246]    [Pg.517]    [Pg.519]    [Pg.18]    [Pg.497]    [Pg.499]   
See also in sourсe #XX -- [ Pg.650 ]



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