Immunostimulatory oligodeoxynucleotide

Weiner, G.J., Liu, H.M., Wooldridge, J.E., Dahle, C.E. and Krieg, A.M. (1997) Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA, 94, 10833-10837. 

Klinman, D. M. and D. Currie (2003) Hierarchical recognition of CpG motifs expressed by immunostimulatory oligodeoxynucleotides. Clin Exp Immunol 133 227-232. 

Bianco A, Hoebeke J, Godefroy S, Chaloin O, Pantarotto D, Briand JP, Muller S, Prato M, Partidos CD (2005a) Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties. J. Am. Chem. Soc. 127 58-59. 

Jakob, T., Walker, P.S., Krieg, A.M., Udey, M.C. and Vogel, J.C. (1998) Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides a role for dendritic cells in the augmentation of Thl responses by immunostimulatory DNA. J. Immunol., 161, 3042-3049. 

Cooper, C.L., Davis, H.L., Morris, M.L., Eller, S.M., Adhami, M.A., Krieg, A.M., Cameron, D.W., Heathcote, J. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults A double blind phase I/II study. J Clin Immunol 24 (2004) 693-701. 

Vollmer J, Weeratna R, Payette P, et al. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol. 2004 34 251-262. 

Oumouna, M., L. Jaso-Friedmann and D.L. Evans. Activation of nonspecific cytotoxic cells (NCC) with synthetic oligodeoxynucleotides and bacterial genomic DNA binding, specificity and identification of unique immunostimulatory motifs. Dev. Comp. Immunol. 26 257-269, 2002. 

Zhao Q, Yu D, Agrawal S (1999) Site of chemical modification in CpG containing phosphorothioate oligodeoxynucleotide modulates its immunostimulatory activity. Bioorg Med Chem Lett 9 3453-3458... 

Yu D, Zhao Q, Kandimalla ER et al (2000) Accessible 5 -end of CpG-containing phospho-rothioate oligodeoxynucleotides is essential for immunostimulatory activity. Bioorg Med Chem Lett 10 2585-2588... 

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