Immunologically primed cells

Sallusto, F., Lanzavecchia, A and Mackay, C.R. (1998) Chemokine and chemokine receptors in T-cell priming and Thl/Th2-mediated responses. Immunology Today 12, 569-574. 

Mitchell GF, Humphrey JH, Williamson AR (1972) B cell tolerance induced by polymeric antigens I. Comparison of the dose and epitope density requirements for inactivation of primed and unprimed B cells in vivo. Eur J Immunol 5 361 Mota I (1964) The mechanism of anaphylaxis I. Production and biological properties of mast cell sensitizing antibody. Immunology 7 681 Neftel KA Waelti M Spengler H Von Felten A Weitzman SA Buergi H de Week AL (1981) Neutropenia after penicillins Toxic or immune-mediated Klin Wochenschr 59 877... 

In 1996 the exosome was discovered to have an immunological function and consequent study of the immunological role of exosomes has been extensive (Raposo et al., 1996). Exosomes have been shown to take part in both T-cell activation (Sprent, 2005) and in tolerance development (Karlsson et al., 2001). It has been shown that exosomes released from mast cells have the capacity to activate T cells and endothelial cells, and in addition to induce DC maturation. Thus, there is now extensive evidence that exosomes can mediate communication between cells over a distance. Furthermore, exosomes primed with specific tumor antigens are under clinical trials for cancer treatment. 

Rustemeyer, T., De Ligter, S., Von Blomberg, B.M., Frosch, P.J., Scheper, R.J. (1999). Human T lymphocyte priming in vitro by haptenated autologous dendritic cells. Clinical and Experimental Immunology, 117, 209-216. 

Figure 4.6 Effect of spleen cells from GAT-primed animals on the PFC response of normal DBA/1 spleen cells to GAT-MBSA in vitro. GAT-primed mice received 10 pg of GAT in Maalox 3 days (experiment I) or 4 days (experiment II) prior to culture initiation. (Taken from Benacerraf, B., Kapp, J. A. and Pierce, C. W. (1974). In D. H. Katz and B. Benacerraf (eds.). Immunological Tolerance Mechanisms and Potential Therapeutic Applications, p. 507. (New York Academic Press, Inc.)...

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