Immunological Recognition of Free, Unconjugated Drug Molecules

3 Immunological Recognition of Free, Unconjugated Drug Molecules 

IgE levels influence IgE receptor density on cells. High levels of antibody increase both the number of FceRI receptors and the degranulation of mast cells and basophils. Along with degranulation, increased release of cytokines such as IL-4 occurs and these in turn stimulate increased IgE levels and receptor density. A reduction of IgE results in a reduction of receptor levels on mast 

Fully activated B cell undergoes clonal expansion and class switchii  

Antigen presentation to activated T cells by activated B cells ultimately results in co-stimulation of the B cells, class switching, clonal expansion, and differentiation to effector cells 

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