Selective immunoglobulin deficiencies

Contraindications Hypersensitivity to human immunoglobulin Selective IgA deficiency ... 

Cataldo F, Marino V, Bottaro G, Greco P, Ventura A. Celiac disease and selective immunoglobulin A deficiency. JPediatr 1997 13 306-308. 

Cataldo F, Marino V, Ventura A, Bottaro G, Corazza GR. Prevalence and clinical features of selective immunoglobulin A deficiency in coeliac disease An Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and Club del Tenue Working Groups on Coeliac Disease. Gut 1998 42 362-365. 

James, S.R, Jones, E.A., Schafer, D.F., Hoofnagle, J.H., Varma, R.R., Strober, W. Selective immunoglobulin A deficiency associated with primary biliary cirrhosis in a family with liver disease. Gastroenterology 1986 90 283-288... 

G23. Gryboski, J. D., Self, T. W., Clemett, A., and Herskovic, T., Selective immunoglobulin A deficiency and intestinal nodular lymphoid hyperplasia correction of diarrhoea with antibiotics and plasma. Pediatrics 42, 833-837 (1968). 

Estimation of autoantibodies in CD is based mainly on detection of IgA class immunoglobulins. However, CD is associated with selective IgA deficiency [131]. About 2% of CD patients are IgA deficient in Italy [132, 133] and Ireland [134]. In cases of IgA deficiency, the corresponding IgG antibodies should be evaluated. Indirect immunofluorescent detection of IgG anti-endomysium antibodies has drawbacks due to secondary antibodies against human IgG often nonspecifically binding to connective tissue fibers [135]. However, IgG class antibodies against tTG have shown high specificity for CD in cases of IgA deficiency [136-139],... 

Bkrandtzaeg, P., Fjellanger, I. and Geruldsen, S.T. (1968). Immunoglobulin M local synthesis and selective secretion in patients with IgA deficiency. Science 160, 789-791. 

B27. Buckley, R. H., and Sidbury, J. B., Hereditary alterations in the immvme response Coexistence of agammaglobulinemia, acquired hypogammaglobulinemia and selective immunoglobulin deficiency in a sibship. Pediat. Res. 2, 72-84 (1968). 

Agammaglobullnaemla There is a complete absence of immunoglobulin production. Selective IgA deficiency is more common with affected children presenting with recurrent respiratory infections... 

X-linked immunodeficiency with increased IgM Selective immunoglobulin deficiencies (dysgamma-globulinaemia)... 

This term is used to describe cases in which there are consistent deficiencies of one or more of the recognizable plasma immunoglobulins. Although often associated with the clinical manifestations of the antibody deficiency syndrome, some instances of selective immunoglobulin deficiency may be chance laboratory findings in otherwise apparently normal individuals. ... 

---