Immunocompromised patients prophylaxis against

Which one of the following drugs is most suitable in an immunocompromised patient for prophylaxis against infection due to Cryptococcus neoformansi... 

In the case of opportunistic candidal infections in the immunocompromised patient, no prophylactic drugs have been shown to be effective. Prophylaxis against other fungi may be effective in some instances, including suppression of cryptococcal meningitis in AIDS patients with fluconazole. However, prophylactic use of azoles may be contributory to the development of fungal resistance. The answer is (E). 

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