Immune cell signaling

Tan SL, Parker PJ. Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J 2003 376(Pt 3) 545-552. 

Dykstra M, Cherukuri A, Sohn HW, Tzeng SJ, Pierce SK. Location is everything lipid rafts and immune cell signaling. Annu. 14. Rev. Immunol. 2003 21 457-481. 

The T-cell specific transcription factor, NFAT is held in the cytosol through the presence of an inhibitory phosphorylated residue. Upon TCR-mediated calcium release, the calcineurin dephosphorylates NFAT, translocates to the nucleus. CsA and FK 506 have proved useful in identifying this pharmaceutically vulnerable step in immune cell signaling [70]. 

Harnett W, Goodridge HS, Harnett MM. Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62. Parasitology 2005 130(Suppl) S63-68. 

Senaratne W, et al. Functionalized surface arrays for spatial targeting of immune cell signaling. J Am Chem Soc 2006 128(17) 5594—5. 

Figure 8.21 ROMP polymers can serve as synthetic antigens to study Immune cell signaling.

SVAJGER u, ANDERLUH M, JERAS M, OBERMAJER N (2010), C-type lectin DC-SIGN an adhesion, signalhng and antigen-uptake molecule that guides dendritic cells in immunity , Cell Signal, 22,1397-405. 

Sharp BM (2003) Opioid receptor expression and intracellular signaling by cells involved in host defense and immunity. Adv Exp Med Biol 521 98-105 Sharp BM (2006) Multiple opioid receptors on immune cells modulate intracellular signaling. Brain Behav Immun 20 9-14... 

Jordan MS, Singer AL, Koretzky GA. Adaptors as central mediators of signal transduction in immune cells. Nat Immunol 2003 4(2) 110-116. 

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