Immortalization of cells

Figure 11.4-2. Immortalization of cells with hTERT. Ectopic expression of hTERT allows cells to bypass proliferation barriers and become immortal. Telomeres are very important in booth senescence (Ml) and crisis (M2) as hTERT introduction either before or after Ml results in cell immortalization. If introduction of hTERT does not result in immortalization in the cells, another type of growth arrest called premature senescence or cell culture shock will be occurred, which is telomere-independent. (This figure is available in full color at ftp //ftp.wiley.com/public/sci tech med/pharmaceutical biotech/.)...

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