Imipenem Theophylline

Isolated seizures that are not epilepsy can be caused by stroke, central nervous system trauma, central nervous system infections, metabolic disturbances (e.g., hyponatremia and hypoglycemia), and hypoxia. If these underlying causes of seizures are not corrected, they may lead to the development of recurrent seizures I or epilepsy. Medications can also cause seizures. Some drugs that are commonly associated with seizures include tramadol, bupropion, theophylline, some antidepressants, some antipsy-chotics, amphetamines, cocaine, imipenem, lithium, excessive doses of penicillins or cephalosporins, and sympathomimetics or stimulants. 

Carbapenems (imipenem more than meropenem) are believed to increase central nervons system excitation by inhibition of GABA binding to receptors. Combinations with other GABA inhibiting drngs snch as theophylline or qninolones have been reported to provoke seizures (45,46). 

Semel JD, Allen N. Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. South Med J 1991 84(4) 465-8. 

Seizures developed in three patients taking aminophylline or theophylline when they were given imipenem. 

Noninterfering amikacin, aztreonam, carbamazepine, cephalosporins, ciprofloxacin, clavulanic acid, difloxacin, digitoxin, digoxin, fleroxacin, fosfomycin, furosemide, gentamicin, imipenem, lidocaine, netilmicin, norfloxacin, ofloxacin, pefloxacin, penicillins, phenobarbital, phenytoin, primidone, procainamide, quinidine, rifampin, salicylic acid, teicoplanin, theophylline, tobramycin, valproic acid, vancomycin... 

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