Proline iminopeptidase

Tamura, T., Tamura, N., Lottspeich, F., and Baumeister, W. Tricorn protease (TRI) interacting factor 1 from Thennoplasma acidophilum is a proline iminopeptidase. FEES Lett. 1996b, 398, 101-105. 

FOSTER-NIEMANN PLOTS PROLINE DEHYDROGENASE PROLINE DIPEPTIDASE PROLINE IMINOPEPTIDASE c/s,trans-Proline isomerization,... 

Sarid, S., Berger, A., and Katchalski, E. Proline iminopeptidase. II. Purification and comparison with iminopeptidase (prolinase). J. Biol. Chem. 237(7) 2207—2212, 1962. 

Habibi-Najafi, M. B., and Lee, B. H. (1995). Purification and characterization of proline iminopeptidase from Lactobacillus casei ssp. easel LLG. J. Dairy Sci. 78, 251-259. 

Panon, G. (1990), Purification and characterization of a proline iminopeptidase from Propionibacterium shermanii 13673. Lait 70, 439-452. 

Proline iminopeptidase [L-Prolylpeptide hydrolase] (3.4.11.5) is produced. [Formerly EC3.4.1.4.] Pyroglutamyl aminopeptidase [L-Pyroglutamyl-peptide hydrolase, Pyrrolidone-carboxylate peptidase] (3.4.11.8) is produced. [Removes pyroglutamate from various penultimate amino acid residues except L-proline. Occurs in Pseudomonas, Bacillus subtilis, rat liver.]... 

Proline-specific peptidases can hydrolyze proUne residues from the A-terminal position of peptides. Proline iminopeptidase (PepI) has aminopeptidase activity towards A-terminal proline peptides and prefers tri-peptides (NH2-Pro, Xn-COOH). The prolinase PepR has a broad specificity for dipeptides (NH2-ProiX-COOH). These proline-specific peptidases are absent from all L. lactis strains. The activity of cell extract fi-om Lact. helveticus and Lact. rhamnosus for several proline dipeptides was significantly reduced in PepR-deletion mutant. Those observations suggest that PepI and PepR may contribute to the specific proteolytic capacity for breaking down peptides containing proline in Lactobacillus strains (Liu et al. 2010). 

---