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2-Imidazolyl anilines

Verma and collaborators reported selective syntheses of 4,5-dihydro-imidazo- and imidazo[l,5-a]quinoxalines via a modified Pictet-Spengler reaction by treating 2-imidazolyl anilines 134 with aromatic aldehydes in the presence ofp-toluenesulfonic acid in toluene (Scheme 66) (13TL5984). [Pg.431]

For the reaction to proceed, an electron-donating substituent on the starting 2-imidazolyl anilines was required. Longer reaction times were observed to provide the auto-oxidation product, quinoxaUne 135, over the reduced product, compound 136. The optimal reaction times for these compounds were determined to be 12 and 2h, respectively. [Pg.432]

An efficient method of selective synthesis of the oxidized and reduced forms of imidazo[l,5-a]quinoxalines via modified Pictet-Spengler reaction of 2-imidazolyl anilines with arylaldehydes (the possible mechanism is shown in Scheme 4.42) has been described (Verma et al. 2013). The reaction proceeds under mild conditions... [Pg.234]


See other pages where 2-Imidazolyl anilines is mentioned: [Pg.149]    [Pg.247]   
See also in sourсe #XX -- [ Pg.431 ]

See also in sourсe #XX -- [ Pg.431 ]




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