Imidazoles tyrosine kinase inhibitor

Mauritamide A (481), a taurine-containing metabolite, was isolated from the sponge Agelas mauritiana [411]. The taurine-containing alkaloids tauroacidins A (482) and B (483) were isolated from a Hymeniacidon sp. from Okinawa and are tyrosine kinase inhibitors [412]. An imidazole alkaloid, (9 )-clathridine 9-A-(2-sulfoethyl)-imine (484), a taurine derivative of clathridine, was isolated from the calcareous sponge... 

In 2008, Fagnou [124] achieved multiple C-H arylations of 1,3-azoles such as thiazoles and imidazoles by converting them into the corresponding azole N-oxides. Subsequently, they accomplished the synthesis of Tie2 tyrosine kinase inhibitor 87... 

In 2010, Mural and Shibahara successfully synthesized the same target via sequential C-H arylation of imidazole using their own catalytic system (Scheme 16.25b) [49a]. They discovered that cationic palladium species [Pd(phen)2](PFg)2 (phen = 1,10-phenanthroline) is more effective than neutral palladium catalysts for the C-H arylation of 1,3-azoles and, in order to demonstrate the utility of their catalyst, the synthesis of tyrosine kinase inhibitor was carried out. Their synthesis... 

IGF-l-RTK, insulin-like growth factor-1 receptor tyrosine kinase IGF-2, insulin-like growth factor-2 IGF-2-RTK, insulin-like growth factor-2 receptor tyrosine kinase iGlu-R, inhibitory glutamate receptor IKK, inhibitor kB kinase IL, interleukin IL-1P, interleukin-1P IL-ip-R, interleukin-ip receptor IL-1, interleukin-1 IL-8, interleukin-8 IL-8-R, interleukin-8-receptor lie, isoleucine Im, imidazole... 

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