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Cyano-imidazoles

Imidazole, 1 -cyano-4-methyl-2-methylthio-synthesis, 5, 494 Imidazole, 4-cyano-2-phenyl-synthesis, 5, 494... [Pg.650]

Imidazo[2,l-c][l,2,4]dithiazole-3-thione HNMR,6, 904 <71TL1317> 4/7-Imidazol-5-amine, 4-cyano-4-methyl- H NMR, 5, 16 <83UP40100>... [Pg.27]

Imidazole-4-catbonitrile, 5-amino-synthesis, 5, 463 Imidazolecarboxamide, cyano-reactions, 5, 436 Imidazole-4-carboxamide Hofmann reaction, 5, 435 Imidazole-4-carboxamide, 5-amino-in histidine biosynthesis, 1, 90 reactions... [Pg.655]

Imidazole-5-carboxamide, 4-cyano-reduction, 5, 435 synthesis, 5, 461, 472 Imidazole-5-carboxamide, 4-mercapto-oxidation, 5, 445... [Pg.655]

Etintidine (84), an imidazole-containing histamine H-2 receptor antagonist, is an antiiilcer agent conceptually related to cimetidine and ranitidine. It can be synthesized by various routes one of which terminates by an addition-elimination reaction of propargylamine with substituted N-cyano-S-methylisothiourea derivative 83 to give etintidine (84) [28]. [Pg.89]

Chemical Name N-cyano-N -methyl,N"-[2-[ [(5-methyl-1 H-imidazol-4-yl)methyl] thio] ethyl] guanidine... [Pg.341]

C5H5N3 98873-55-3) see Lanoconazole A -cyano-Ai -[2-([(5-methyl-lH-imidazol-4-yl)mcthylJ-thio]ethyl]carbamimidothioic acid methyl ester (C, H 5N5S2 52378-40-2) see Cimetidine... [Pg.2339]

Reaction of trisubstituted imidazole N-oxides such as l,4,5-trimethylimidazole-3-oxide 930 with 18/NEt3 in CH2CI2 at 0-5 °C affords the l,4,5-trimethyl-2-cyano-... [Pg.156]

Ethyl substitution at the imidazole 5-position (469) was found to increase potency over the unsubstituted analogue (468), while methyl substitution (470) had a slightly deleterious effect on binding (Table 6.41). Chloro (491), bromo (492), cyano (493) and fluoromethyl (494) substitution at this position were all well tolerated (Table 6.43). Introduction of a chloro-substituted pyridine (475) in place of the more usual / -chlorophenyl group (470) resulted in a slight loss of affinity for the CBi receptor, as did replacement of the p-chloro group of (470) with bromo (471), fluoro (472) and in particular, met-hoxy (473). Trifluoromethyl substitution (474) however, was well tolerated. [Pg.289]

Four tetramers of hydrogen cyanide have been isolated the well-known diaminomaleonitrile (DAMN), diaminofumaronitrile, 4-amino-5-cyano-imidazole, and an HCN adduct of s-triazine. [Pg.4]

See other pages where Cyano-imidazoles is mentioned: [Pg.650]    [Pg.650]    [Pg.650]    [Pg.313]    [Pg.650]    [Pg.650]    [Pg.650]    [Pg.650]    [Pg.8]    [Pg.592]    [Pg.649]    [Pg.649]    [Pg.650]    [Pg.249]    [Pg.213]    [Pg.173]    [Pg.154]    [Pg.156]    [Pg.921]    [Pg.135]    [Pg.190]    [Pg.222]    [Pg.530]    [Pg.137]    [Pg.1000]    [Pg.65]    [Pg.629]    [Pg.107]    [Pg.151]    [Pg.1561]    [Pg.151]    [Pg.154]    [Pg.154]    [Pg.119]    [Pg.140]    [Pg.141]    [Pg.87]    [Pg.168]    [Pg.580]    [Pg.581]    [Pg.581]    [Pg.267]   
See also in sourсe #XX -- [ Pg.271 ]



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