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Imidazole acetic acid riboside

Methylated imidazole derivatives, imidazole acetic acid riboside (D 20) Urine... [Pg.487]

Biosynthesis is performed in one step by the enzyme L-histidine decarboxylase (HDC, E.C. 4.1.1.22). Histamine metabolism occurs mainly by two pathways. Oxidation is carried out by diamine oxidase (DAO, E.C. 1.4.3.6), leading to imidazole acetic acid (IAA), whereas methyla-tion is effected by histamine N-methyltransferase (HMT, E.C. 2.1.1.8), producing fe/e-methylhistamine (t-MH). IAA can exist as a riboside or ribotide conjugate. t-MH is further metabolized by monoamine oxidase (MAO)-B, producing fe/e-methylimidazole acetic acid (t-MIAA). Note that histamine is a substrate for DAO but not for MAO. Aldehyde intermediates, formed by the oxidation of both histamine and t-MH, are thought to be quickly oxidized to acids under normal circumstances. In the vertebrate CNS, histamine is almost exclusively methylated... [Pg.253]

See other pages where Imidazole acetic acid riboside is mentioned: [Pg.422]    [Pg.699]    [Pg.181]    [Pg.191]    [Pg.422]    [Pg.699]    [Pg.181]    [Pg.191]    [Pg.320]   
See also in sourсe #XX -- [ Pg.382 , Pg.487 ]



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