Imidazo quinoxalines biological activity

There has been developed a convenient and efficient domino process for con-stmcting benz[4,5]imidazo[l,2-a]quinoxalines 173 from A/-tosyl-2-haloanilines 174 and 2-(chloromethyl)-lff-benzimidazoles 175 (Scheme 4.76). This reaction proceeds under mild conditions and is catalyzed by copper salts, and the yields vary from moderate to quantitative. Such a Cu-catalyzed one-pot method can be used for synthesis of a large number of compounds with the aim of testing their biological activity. 

As can be seen from the material presented in this review, imidazo[l,5-a]- and imidazo[l,2-a]quinoxalines arouse a great deal of interest of researchers owing to the wide range of biological activity exhibited by them. For this reason, in addition to the improvement of the known methods of their synthesis, an intensive search is carried out for new preparative procedures that afford diverse derivatives. 

One of the important new areas of biological studies of imidazo[l,5-fl]- and imidazo[l,2-a]quinoxaline derivatives focuses on their antitumour activity. New potent dual CK2 and PIM kinase inhibitors with the antiproliferative activity against cancer cells have been described (Pierre et al. 2012), for example, compound 184 (IC50 = 0.038 (PIMl), 0.043 (P1M2), 0.035 (CK2) mol L ). 

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