2- -imidazo pyridine, activity

T. Granier, N. Panday, and A. Vasella, Structure-activity relations of imidazo-pyridine-type inhibitors of P-D-glucosidases, Helv. Chim. Acta, 80 (1997) 979-987. 

Several alkylcobaloximes have been degraded by acetic anhydride in pyridine to an imidazo-pyridine, and a key step in a complicated sequence is the migration of pyridine from cobalt to an activated ligand (Scheme 56).179... 

Z-aminO 1 -methy 1 6 phenylimidazo [4,5-b]-pyridine 2 aminO 3,7,8 trimethylimidazo[4,5 f]quinoxaline 2 aminO 3,4,7,8 tetramethyl 3H imidazO [4,5 f]quinoxaline inoxaline 3 aminO l,4 dimethyl SH pyrid [4,3 b] indole (Trp P I) and 3 aminO l methyl 5H pyrido [4,3 b]indole induced mutagenesis. Metabolic activation was required for positive results b... 

A number of imidazo[4,5-c]pyridine nucleosides (3-deazapurine nucleosides) are of special interest because of their biological properties. 3-Deazaadenosine (655) inhibits biochemical methylations by acting as either an inhibitor or substrate of (S)-adenosylhomocysteine hydrolase <79BP1897>. Compound (655) has antiviral <78BBR(82)417> and antimalarial activities <80MI 708-01). 3-Deaz-... 

McKenna, C.E., et al. (2010). Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent New geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[l,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med... 

Imidazo[l,2-a]pyridines (58) activated by a nitro group at C-6 or C-8 undergo the Dimroth rearrangement to (60) in aqueous base. Intermediates of the rearrangement (59) were detected and their structures investigated spectroscopically (73JHC755). 

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