Imaging opioid receptors

Henriksen G, Willoch P (2008) Imaging of opioid receptors in the central nervous system. Brain 131 1171-1196... 

DOR delta-opioid receptor fMRI functional magnetic resonance imaging... 

Opioid receptor binding data have been reported for a series of 17-cyclopropyl-methylnoraminomorphindole derivatives (59, Fig. 13) [56]. All but the propyla-mino derivative (59b) had subnanomolar affinity for DOR which reduced its DOR selectivity compared with ethylamino- (59a) which was the only new ligand comparable in selectivity with naltrindole (58b). The indolic-substituted formyla-mino- derivatives were investigated as potential PET ligands for imaging studies of DOR. Alkylation of the indolic /V-atom allowed retention of high affinity for DOR. The fluoroethyl substituent (59d) had little effect on selectivity but fluoropropyl (59e) lowered selectivity. 

K. C. Black et al.. Gold nanorods targeted to delta opioid receptor Plasmon-resonant contrast and photothermal agents. Molecular Imaging, 7(1), 50-57 (2008). 

Madar I, Lever JR, Kinter CM, Scheffel U, Ravert HT, Musachio JL, Mathews WB, Dannals RF, Frost JJ. Imaging of delta opioid receptors in human brain by Nl -([ C]methyl)naltrindole and PET. S3mapse 1996 24 19-28. 

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