Ilex crenata

In the search for potential antiallergic compounds, the inhibition of ConA-induced histamine release from rat peritoneal mast cells has been measured as a monitor in separation and fractionation of active compounds [91]. On the basis of this in vitro test, ilexosides A, B, C and D (66-69), four novel 18,19-seco-ursane glycosides isolated from Ilex crenata... 

Similar rearrangements in the ursane series (cf. cation 530) are known but appear to be of minor consequence in elaborating new compounds no more than a dozen triterpenoids belonging to all these types (cf. Fig. 8.1.32) have been isolated so far. Of these, only baueranes (corresponding to the multiflorane type) (Fig. 8.1.32) have been encountered in woody tissues. Thus, the simplest member, bauerenol (554), has been found to occur in the barks of Acronychia baueri and Ilex crenata (229). Phyllanthol (555), from the root-bark of Phyllanthus engleri, represents an alternative fate for the isoursane cation (ursane equivalent of cation 543) (109, 228). 

Of the 42 species of Ilex tested, only four were regarded as positive I. cassine, I. coriacea, I. crenata, and./, glabra (2/3). I. cassine and I. crenata had previously been reported as alkaloid-positive. The purines do not give definitive alkaloid tests with the Dragcndorff reagent and are not considered true alkaloids by some investigators. 

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