Ventricular fibrillation idiopathic

Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 1998 392 293-296. 

Shu J, Zhu T, Yang L, Cui C, Yan GX. ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome cellular and clinical linkage. J Electrocardiol 2005 38 26. 

Noehe/s There are several mutations in SCNSA which cause idiopathic ventricular fibrillation (Chen et al 1998). It is pretty rare. 

Wan X, Wang Q, Kirsch GE 2000 Functional suppression of sodium channels by /il-suburiiis as a molecular mechanism of idiopathic ventricular fibrillation. J Mol Cell Cardiol 32 1873-1884... 

Long (and short) QT interval syndrome Right ventricular dysplasia Hypertrophic cardiomyopathy Idiopathic ventricular fibrillation Infiltrative heart disease Amyloidosis Sarcoidosis Hemochromatosis... 

Ablation may treat bundle-branch reentry and fascicular forms of ventricular tachycardia effectively (142-144). Ablation of Purkinje fibers may reduce the risk of idiopathic ventricular fibrillation initiated by a PVC (76) and some forms of ventricular tachycardia (145). Substrate modification can reduce specific forms of recurrent monomorphic ventricular tachycardias in patients with structural heart disease (138,146-149), particularly if the patient is having storms of tachycardia Therefore, occasionally, ablation performed during electrophysiology testing can modify the ventricular tachycardia recurrences... 

ICD implantation should be considered for this latter group. Idiopathic ventricular fibrillation is not a reason to consider drug therapy. An ICD should... 

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