Identification of Parameter Values

Because of the lack of good experimental data in human brain chemistry, our presentation is limited to the use of carefully chosen normalized experimental parameters in order to reproduce the basic static and dynamic characteristics of this coupled enzymes system. 

Most of the data is taken from earlier experimental work. The concentrations in the feed and reference values are taken from mouse and rat brain data for the sake of illustration. The membrane permeability parameters for S2 and S3 are assumed equal to the value for si. The normalized parameter is taken equal to I 2, which was found earlier experimentally. The kinetic parameters 6m for m = 1. 8 of reaction (1) are chosen by using a known dissociation constant and by keeping the experimentally found proportion for reaction (2) on substrate-inhibition and hydrogen-ion effects. 

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