Zaleplon ibuprofen

The interaction of zaleplon with ibuprofen has been investigated in 17 subjects (23). Healthy adult volunteers were given zaleplon 10 mg alone, ibuprofen 600 mg alone, or zaleplon 10 mg plus ibuprofen 600 mg in an open, randomized, crossover study. The adverse effects were mild and resolved without intervention. The authors concluded that there was no evidence of a significant interaction between zaleplon and ibuprofen. 

Sanchez Garcia P, Carcas A, Zapater P, Rosendo J, Paty I, Leister CA, Troy SM. Absence of an interaction between ibuprofen and zaleplon. Am J Health Syst Pharm 2000 57(12) 1137-41. 

Diclofenac reduces the dose of midazolam needed to produce sedation and hypnosis. Diazepam has a small effect on the pharmacokinetics of diclofenac, ibuprofen and naproxen. Diazepam and indometacin appear not to interact adversely, although feelings of dizziness may be increased. Zaleplon and ibuprofen appear not to interact... 

A randomised, single-dose study in 17 healthy subj ects found that ibuprofen 600 mg had no effect on the pharmacokinetics of zaleplon 10 mg. ... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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