Ibogaine anti-addictive properties

Ibogaine (4, NIH 101567, Endabuse ), a natural alkaloid found in the root, rootbark, stem and leaves of the African shrub Tabernanthe iboga, was isolated over 100 years ago [5,6,7]. Its structure was established some 50 years later [8], and subsequently its first total synthesis was reported by Buchi [9]. Informative reviews of history, chemistry, mechanisms of action, pharmacokinetic properties, metabolism, neurochemical and anti-addictive properties have been published over the last decade [10,11,12]. Recently it has been... 

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