I- Naproxen

The introduction of electronic asymmetry into this class of bis(diaryl)phosphinites has been used to design catalysts that can afford both enantiomers of naproxen nitrile. If the carbohydrate scaffold is based on methyl o-D-fructol uranosidc (29), (i )-naproxen nitrile is produced. In a similar manner to the results above, electron-donating aryl substituents on phosphorus afford... 

Since naproxen is a carboxylic acid, they chose to make the carboxylate salt of an enantio-merically pure amine, and found that the most effective was this glucose derivative. Crystals were formed, which consisted of the salt of the amine and (S)-naproxen, the salt of the amine with (i )-naproxen (the diastereoisomer of the crystalline salt) being more soluble and so remaining in solution. These crystals were hltered off and treated with base basic, releasing the amine (which can later be recovered and reused) and allowing the (S)-naproxen to crystallize as its sodium salt. 

Acetaminophen, arachidonic acid, benzo[a]pyrene, clozapine, cyclophosphamide, dapsone, dorzolamide, (i2)-fluoxetine, hexobarbital,(S)- and (f2)-ibuprofen, lauric acid, losartan, (S)- and (i )-naproxen, N-nitrosodimethylamine,ondansetron, phenylbutazone, piroxicam, 9-cis-retinoic acid, sulfadiazine, sulfamethoxazole, tetrahydrocannabinol, torasemide, trimethoprim,... 

NAPROXEN MODAEINIL May cause i naproxen levels if CYPl A2 is the predominant metabolic pathway and alternative metabolic pathways are either genetically deficient or affected Modafinil is moderate inducer of CYPl A2 in a concentration-dependent manner Be aware... 

FIGURE 9.7 Three-dimensional representation of the skewed chromatographic peak shapes of (a) 5-(- -)-naproxen (left-handed) and (b) i -(—)-naproxen (right-handed). (From Sajewicz, M., Pietka, R., Drabik, G., Namyslo, E., and Kowalska, T., J. Planar Chromatogr. —Mod. TLC, 19, 273-277, 2006. With permission.)... 

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