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I-BuOCOCl

The synthesis of BIRT-377 (1) is outlined in Scheme 4. The commercially available (D)-iV-Boc-alanine (13) reacted with 3,5-dichloroaniline via a mixed anhydride intermediate (i-BuOCOCl, iV-methylmorpholine, -10 °C to rt, THF) to give amide 14. Deprotection of the crude amide 14 with trifluoroacetic acid in dichloromethane afforded amino iV aryl amide 15 in 92% yield over two steps. This crude product was pure enough to carry on for next step without any purification. [Pg.27]

See other pages where I-BuOCOCl is mentioned: [Pg.601]    [Pg.130]    [Pg.695]    [Pg.601]    [Pg.267]    [Pg.283]    [Pg.634]    [Pg.163]    [Pg.267]    [Pg.243]    [Pg.243]    [Pg.601]    [Pg.130]    [Pg.695]    [Pg.601]    [Pg.267]    [Pg.283]    [Pg.634]    [Pg.163]    [Pg.267]    [Pg.243]    [Pg.243]    [Pg.654]    [Pg.205]   
See also in sourсe #XX -- [ Pg.283 ]



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