Hyrtiomanzamine immunosuppressive activity

Hyrtiomanzamine (493), a compound consisting of a 6-hydroxy-(J-carboline associated with a betaine unit, was isolated from Hyrtios erecta from the Red Sea and the structure elucidated by spectral data examination. Hyrtiomanzamine exhibited immunosuppressive activity in the B lymphocytes reaction assay [419],... 

Manzamine-type alkaloids were also reported in another samples of marine sponges, eg., the Okinawan Amphimedon sp. [252-254], Pachypellina sp. [255], and a novel alkaloid called hyrtiomanzamine from Hyrtios erecta, with interesting immunosuppressive activity [256]. From... 

The New Zealand bryozoan Cribicellina cribraria was the source of several P-carboline alkaloids. One of these examples, compound 34, has a unique methylsulfone substituent. Spectroscopic studies identified 34 as 1-ethyl-4-methylsulfone-P-carboline [34]. Hyrtiomanzamine (35) represents the first example of a 6-OH-P-carboline ring associated with a betaine unit to be obtained from a natural source. This compound was isolated from the Red Sea sponge Hyrtios erecta and its structure was determined on the basis of its spectral data [35]. Compound 35 displayed immunosuppressive activity with an ED50 of 2 mg/ml in the B lymphocytes reaction assay. The lack of cytotoxicity against KB cells indicated that the immunosuppressive activity of 35 is specific and not due to a general cytotoxic effect. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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