Hypoxic chemoreceptor-like

The most compelling evidence that the pre-BotC has the capacity to play a hypoxic chemoreceptor-like role in respiratory control comes from studies in which we examined the effects of systemic hypoxia on respiratory output before and after... 

It is our view that the most convineing examples of direct, i.e., chemoreceptor-like, hypoxic excitation of motor output mediated by discrete sites in the CNS are excitation of sympathetic discharge and gasping brought about by severe brain hypoxia. 

Here, we argue that the pre-BotC has the capacity to manifest a chemoreceptor-like function (i.e., act as a primary hypoxic transducer), and that this capacity is most readily apparent when the neurons in this region are released from strong GABAergic inhibition. First, we (and others) have shown that the pre-BdtC is a key site of excitatory input to the respiratory motor output. Microinjection of the... 

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