Hypoxia-sensing

From these studies, it is now possible to construct a generalized framework or working hypothesis for how hypoxia-tolerant cells respond to oxygen lack (figure 3.18). During the very early acute phases, a poorly understood hypoxia-sensing and signal transduction system orchestrates a series of molecular hypoxia defense processes, which include ... 

Semenza GL (2001) HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 13(2/167-171... 

As discussed above, inhibition of Ca -dependent BK channels appears to be an important step in hypoxia sensing by neonatal AMC. Exposure of such cultures to hypoxia (5 and 10% O2) for lhr has previously been shown to stimulate CA... 

TDAG8 appears restricted to the immune system. As tissue inflammation is usually followed by local hypoxia and acidosis, the pH-sensing property of TDAG8 appeared of particular interest in this context. Unexpectedly, however, the phenotype of mice... 

The ability to maintain 02 homeostasis is essential to the survival of all invertebrate and vertebrate species. It is appreciated that all nucleated cells in the human body sense 02 availability (hypoxia) that is either acute or chronic in duration... 

Ryan HE, Lo J, Johnson RS (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17(11) 3005-3015 Semenza GL (1999) Perspectives on oxygen sensing. Cell 98(3) 281-284 Semenza GL (2000) HIF-1 mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88(4) 1474-1480... 

Oxygen Sensing Responses and Adaptation to Hypoxia, edited by S. Lahiri, G. L. Semenza, and N. R. Prabhakar... 

Because of their super-efficient lungs (one-way air flow), birds are sometimes thought to be in a sense preadapted for hypoxia, but within this... 

Acute high-altitude studies of both human and animal models indicate that hypoxia defenses are initiated by several oxygen sensing, signal transduction pathways. For convenience, these have been summarized as five general hypoxia response systems (figure 5.2(A)-(E) ... 

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