Hypoxia-Induced Tissue Reshaping and Remodeling in the Carotid Body

Chronic Hypoxia-Induced Tissue Reshaping and Remodeling in the Carotid Body 

In experiments that evaluated the mechanisms involved in CH-induced tissue remodeling in the carotid body, we examined the effects of suramin, a well-known purinergic P2 receptor antagonist, which is also a nonspecific blocker of growth factor receptors. This drug was of particular interest because it had previously been 

Marcel Dekker, Inc. 270 Madison Avenue, New York, New Yoik 10016 

Our assessment of VEGF and FIk-1 receptor transcript levels in the carotid body indicates that, as in the lung, CH elevates the expression of both. In these studies extracted mRNA was converted to cDNA using conventional methods for 

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